Cancer Center Member Publications and Abstracts Site

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Richard M Pope, MDEdit profile     Publications     Word cloud      
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Academic TitleNorthwestern Medical Faculty Foundation
DepartmentMedicine, Rheumatology Division; Feinberg School of Medicine
AffiliationsNon-Programmatically Aligned (Member)
CampusChicago
AddressMCGAW 240 E Huron St RM 2314 CH 2909
Telephone+1 312 503 8003
Email
DescriptionMacrophages are critical to the regulation of a variety of cancers. The research in our laboratory focuses on the mechanisms that regulate macrophage differentiation and activition. We have recently shown that the deletion of the anti-apoptotic gene FLIP in macrophages, results in a marked reduction of macrophages in the spleen, lymph nodes and peritoneal space. This results in a marked disorganization of lymph nodes and spleen, a marked increase of neutrophils in the circulation and tissues. When FLIP was deleted, precursor cells were incapable of differentiating into macrophages. These observations suggest that FLIP may a target to regulate macrophage cell numbers in maligancy and inflammatory diseases. Additionally our laboratory is examing the role of endogous Toll like receptor ligands in the activation of macrophages. Endogenous Toll like receptor ligands may be import in chronic inflammatory diseases and malignancy.
InterestsApoptosis, macrophage biology and signal transduction, Arthritis, Cytokines, Gene Regulation, Signal Transduction
PubMed IDs
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Publications (178)

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Publications
Huang, Q. Q.; Perlman, H.; Birkett, R.; Doyle, R.; Fang, D.; Haines, G. K.; Robinson, W.; Datta, S.; Huang, Z.; Li, Q. Z.; Phee, H.; Pope, R. M. CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.Nat Commun (2015) 6:7086. 25963626; PMC4429912; 10.1038/ncomms8086
Huang, Q. Q.; Birkett, R.; Koessler, R. E.; Cuda, C. M.; Haines, G. K. 3rd; Jin, J. P.; Perlman, H.; Pope, R. M. Fas Signaling in Macrophages Promotes Chronicity in K/BxN Serum-Induced Arthritis.Arthritis Rheumatol (2014) 66:68-77. 24431281; 10.1002/art.38198
Sun, X.; Olivier, A. K.; Liang, B.; Yi, Y.; Sui, H.; Evans, T. I.; Zhang, Y.; Zhou, W.; Tyler, S. R.; Fisher, J. T.; Keiser, N. W.; Liu, X.; Yan, Z.; Song, Y.; Goeken, J. A.; Kinyon, J. M.; Fligg, D.; Wang, X.; Xie, W.; Lynch, T. J.; Kaminsky, P. M.; Stewart, Z. A.; Pope, R. M.; Frana, T.; Meyerholz, D. K.; Parekh, K.; Engelhardt, J. F. Lung Phenotype of Juvenile and Adult CFTR-Knockout Ferrets.Am J Respir Cell Mol Biol (2014) 50:502-512. 24074402; PMC4068938; 10.1165/rcmb.2013-0261OC
Bhattacharyya, S.; Kelley, K.; Melichian, D.; Tamaki, Z.; Fang, F.; Su, Y.; Feng, G.; Pope, R. M.; Budinger, G. R.; Mutlu, G. M.; Lafyatis, R.; Radstake, T.; Feghali-Bostwick, C.; Varga, J. Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-ss Responses: A Novel Mechanism for Maintaining and Amplifying Fibrosis in Scleroderma.Am J Pathol (2013) 182:192-205. 23141927; PMC3538029; 10.1016/j.ajpath.2012.09.007
Chamberlain, N. D.; Kim, S. J.; Vila, O. M.; Volin, M. V.; Volkov, S.; Pope, R. M.; Arami, S.; Mandelin, A. M. 2nd; Shahrara, S. Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFalpha in monocytes.Ann Rheum Dis (2013) 72:418-426. 22730373; 10.1136/annrheumdis-2011-201203
Huang, Q. Q.; Koessler, R. E.; Birkett, R.; Perlman, H.; Xing, L.; Pope, R. M. TLR2 deletion promotes arthritis through reduction of IL-10.J Leukoc Biol (2013) 93:751-759. 23446149; PMC3629443; 10.1189/jlb.0912473
Huang, Q. Q.; Pope, R. M. The Role of Glycoprotein 96 in the Persistent Inflammation of Rheumatoid Arthritis.Arch Biochem Biophys (2013) 530:1-6. 23257071; PMC3558611; 10.1016/j.abb.2012.12.008
Majka, D. S.; Liu, K.; Pope, R. M.; Karlson, E. W.; Vu, T. H.; Teodorescu, M.; Chang, R. W. Antiphospholipid antibodies and sub-clinical atherosclerosis in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort.Inflamm Res (2013) 62:919-927. 23959159; PMC4122510; 10.1007/s00011-013-0652-x
Pope, R. M.; Shahrara, S. Possible roles of IL-12-family cytokines in rheumatoid arthritis.Nat Rev Rheumatol (2013) 9:252-256. 23090510; 10.1038/nrrheum.2012.170
Rappa, G.; Mercapide, J.; Anzanello, F.; Pope, R. M.; Lorico, A. Biochemical and biological characterization of exosomes containing prominin-1/CD133.Mol Cancer (2013) 12:62. 23767874; PMC3698112; 10.1186/1476-4598-12-62
Sanders, P. N.; Koval, O. M.; Jaffer, O. A.; Prasad, A. M.; Businga, T. R.; Scott, J. A.; Hayden, P. J.; Luczak, E. D.; Dickey, D. D.; Allamargot, C.; Olivier, A. K.; Meyerholz, D. K.; Robison, A. J.; Winder, D. G.; Blackwell, T. S.; Dworski, R.; Sammut, D.; Wagner, B. A.; Buettner, G. R.; Pope, R. M.; Miller, F. J. Jr; Dibbern, M. E.; Haitchi, H. M.; Mohler, P. J.; Howarth, P. H.; Zabner, J.; Kline, J. N.; Grumbach, I. M.; Anderson, M. E. CaMKII Is Essential for the Proasthmatic Effects of Oxidation.Sci Transl Med (2013) 5:195ra97. 23884469; 10.1126/scitranslmed.3006135
Skamra, C.; Romero-Diaz, J.; Sandhu, A.; Huang, Q.; Lee, J.; Pearce, W.; McPherson, D. D.; Sutton-Tyrrell, K.; Pope, R.; Ramsey-Goldman, R. Telomere length in patients with systemic lupus erythematosus and its associations with carotid plaque.Rheumatology (Oxford) (2013) 52:1101-1108. 23382361; PMC3651615; 10.1093/rheumatology/kes424
Carroll, R. J.; Thompson, W. K.; Eyler, A. E.; Mandelin, A. M.; Cai, T.; Zink, R. M.; Pacheco, J. A.; Boomershine, C. S.; Lasko, T. A.; Xu, H.; Karlson, E. W.; Perez, R. G.; Gainer, V. S.; Murphy, S. N.; Ruderman, E. M.; Pope, R. M.; Plenge, R. M.; Kho, A. N.; Liao, K. P.; Denny, J. C. Portability of an algorithm to identify rheumatoid arthritis in electronic health records.J Am Med Inform Assoc (2012) 19:e162-e169. 22374935; PMC3392871; 10.1136/amiajnl-2011-000583
Chamberlain, N. D.; Vila, O. M.; Volin, M. V.; Volkov, S.; Pope, R. M.; Swedler, W.; Mandelin, A. M. 2nd; Shahrara, S. TLR5, a Novel and Unidentified Inflammatory Mediator in Rheumatoid Arthritis that Correlates with Disease Activity Score and Joint TNF-alpha Levels.J Immunol (2012) 189:475-483. 22661088; PMC3614068; 10.4049/jimmunol.1102977
Cuda, C. M.; Agrawal, H.; Misharin, A. V.; Haines, G. K. 3rd; Hutcheson, J.; Weber, E.; Schoenfeldt, J.; Mohan, C.; Pope, R. M.; Perlman, H. Myeloid cell-specific Fas expression is required to prevent systemic autoimmunity.Arthritis Rheum (2012) 64:808-820. 22143975; PMC3290732; 10.1002/art.34317
Huang, Q. Q.; Koessler, R. E.; Birkett, R.; Dorfleutner, A.; Perlman, H.; Kenneth Haines, G. 3rd; Stehlik, C.; Nicchitta, C. V.; Pope, R. M. Gp96 prpetuates the persistent inflammation of rheumatoid arthritis.Arthritis Rheum (2012) 64:3638-3648. 22777994; PMC3473144; 10.1002/art.34610
Humbert, M. C.; Weihbrecht, K.; Searby, C. C.; Li, Y.; Pope, R. M.; Sheffield, V. C.; Seo, S. ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.Proc Natl Acad Sci U S A (2012) 109:19691-19696. 23150559; PMC3511769; 10.1073/pnas.1210916109
Pickens, S. R.; Chamberlain, N. D.; Volin, M. V.; Pope, R. M.; Talarico, N. E.; Mandelin, A. M. 2nd; Shahrara, S. Role of the CCL21 and CCR7 pathway in rheumatoid arthritis angiogenesis.Arthritis Rheum (2012) 64:2471-2481. 22392503; PMC3409328; 10.1002/art.34452
Shi, B.; Huang, Q.; Tak, P. P.; Vervoordeldonk, M. J.; Huang, C. C.; Dorfleutner, A.; Stehlik, C.; Pope, R. M. SNAPIN: an endogenous toll-like receptor ligand in rheumatoid arthritis.Ann Rheum Dis (2012) 71:1411-1417. 22523426; 10.1136/annrheumdis-2011-200899
Huang, C. C.; Liu, K.; Pope, R. M.; Du, P.; Lin, S.; Rajamannan, N. M.; Huang, Q. Q.; Jafari, N.; Burke, G. L.; Post, W.; E Watson, K.; Johnson, C.; Daviglus, M. L.; Lloyd-Jones, D. M. Activated TLR Signaling in Atherosclerosis among Women with Lower Framingham Risk Score: The Multi-Ethnic Study of Atherosclerosis.PLoS One (2011) 6:e21067. 21698167; PMC3116882; 10.1371/journal.pone.0021067

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Last updated from PubMed on Friday, February 05, 2016