Cancer Center Member Publications and Abstracts Site

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Robert David Goldman, PhDEdit profile     Publications     Word cloud      
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Academic TitleStephen W Ranson Professor
DepartmentCell and Molecular Biology; Feinberg School of Medicine
AffiliationsTranslational Research in Solid Tumors (Member)
Tumor Invasion, Metastasis & Angiogenesis (Member)
AddressWARD 303 E Chicago Ave WARD 11-145 CH W129
Telephone+1 312 503 4215

The intermediate filament (IF) network is utilized by cells to establish intracellular connections from the cell surface to the nucleus. Disruption of IF structures is associated with a large variety of disease states and aberrant IF expression is observed in many tumor cells. Dr. Goldman focuses on the structure and function of IF networks in normal and neoplastic fibroblasts and epithelial cells. This large family of proteins establishes networks throughout the cytoplasm and the nucleus. Recently, Dr. Goldman demonstrated that nuclear IFs (lamins) form a nucleoplasmic network that is involved in regulation of DNA replication. Because the IF system forms a dynamic network linking the nuclear and cell surfaces, additional studies are underway to examine the contribution of IFs to diverse cellular processes such as maintenance of cell shape, organelle movements, nuclear positioning, signal transduction and chromatin organization.

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Publications (223)

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Bercht Pfleghaar, K.; Taimen, P.; Butin-Israeli, V.; Shimi, T.; Langer-Freitag, S.; Markaki, Y.; Goldman, A. E.; Wehnert, M.; Goldman, R. D. Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.Nucleus (2015) 6:66-76. 25738644; 10.1080/19491034.2015.1004256
Butin-Israeli, V.; Adam, S. A.; Jain, N.; Otte, G. L.; Neems, D.; Wiesmuller, L.; Berger, S. L.; Goldman, R. D. Role of Lamin B1 in chromatin instability.Mol Cell Biol (2015) 35:884-898. 25535332; PMC4323489; 10.1128/MCB.01145-14
Chernoivanenko, I. S.; Matveeva, E. A.; Gelfand, V. I.; Goldman, R. D.; Minin, A. A. Mitochondrial membrane potential is regulated by vimentin intermediate filaments.FASEB J (2015) 29:820-827. 25404709; 10.1096/fj.14-259903
Koster, S.; Weitz, D. A.; Goldman, R. D.; Aebi, U.; Herrmann, H. Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks.Curr Opin Cell Biol (2015) 32:82-91. 25621895; PMC4355244; 10.1016/
Guo, M.; Ehrlicher, A. J.; Jensen, M. H.; Renz, M.; Moore, J. R.; Goldman, R. D.; Lippincott-Schwartz, J.; Mackintosh, F. C.; Weitz, D. A. Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy.Cell (2014) 158:822-832. 25126787; PMC4183065; 10.1016/j.cell.2014.06.051
Guo, Y.; Kim, Y.; Shimi, T.; Goldman, R. D.; Zheng, Y. Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins.Mol Biol Cell (2014) 25:1287-1297. 24523288; PMC3982994; 10.1091/mbc.E13-11-0644
Kochin, V.; Shimi, T.; Torvaldson, E.; Adam, S. A.; Goldman, A.; Pack, C. G.; Melo-Cardenas, J.; Imanishi, S. Y.; Goldman, R. D.; Eriksson, J. E. Interphase phosphorylation of lamin A.J Cell Sci (2014) 127:2683-2696. 24741066; PMC4058112; 10.1242/jcs.141820
Shabbir, S. H.; Cleland, M. M.; Goldman, R. D.; Mrksich, M. Geometric control of vimentin intermediate filaments.Biomaterials (2014) 35:1359-1366. 24268665; PMC3875369; 10.1016/j.biomaterials.2013.10.008
Shimi, T.; Goldman, R. D. Nuclear lamins and oxidative stress in cell proliferation and longevity.Adv Exp Med Biol (2014) 773:415-430. 24563359; 10.1007/978-1-4899-8032-8_19
Wallace, T. A.; Downey, R. F.; Seufert, C. J.; Schetter, A.; Dorsey, T. M.; Johnson, C. A.; Goldman, R.; Loffredo, C. A.; Yan, P.; Sullivan, F. J.; Giles, F. J.; Wang-Johanning, F.; Ambs, S.; Glynn, S. A. Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.Carcinogenesis (2014) 35:2074-2083. 24858205; PMC4146419; 10.1093/carcin/bgu114
Wood, A. M.; Rendtlew Danielsen, J. M.; Lucas, C. A.; Rice, E. L.; Scalzo, D.; Shimi, T.; Goldman, R. D.; Smith, E. D.; Le Beau, M. M.; Kosak, S. T. TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends.Nat Commun (2014) 5:5467. 25399868; PMC4235626; 10.1038/ncomms6467
Adam, S. A.; Butin-Israeli, V.; Cleland, M. M.; Shimi, T.; Goldman, R. D. Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.Nucleus (2013) 4:142-150. 23475125; PMC3621746; 10.4161/nucl.24089
Butin-Israeli, V.; Adam, S. A.; Goldman, R. D. Regulation of nucleotide excision repair by nuclear lamin b1.PLoS One (2013) 8:e69169. 23894423; PMC3722182; 10.1371/journal.pone.0069169
Funkhouser, C. M.; Sknepnek, R.; Shimi, T.; Goldman, A. E.; Goldman, R. D.; Olvera de la Cruz, M. Mechanical model of blebbing in nuclear lamin meshworks.Proc Natl Acad Sci U S A (2013) 110:3248-3253. 23401537; PMC3587257; 10.1073/pnas.1300215110
Guo, M.; Ehrlicher, A. J.; Mahammad, S.; Fabich, H.; Jensen, M. H.; Moore, J. R.; Fredberg, J. J.; Goldman, R. D.; Weitz, D. A. The Role of Vimentin Intermediate Filaments in Cortical and Cytoplasmic Mechanics.Biophys J (2013) 105:1562-1568. 24094397; PMC3791300; 10.1016/j.bpj.2013.08.037
Mahammad, S.; Murthy, S. N.; Didonna, A.; Grin, B.; Israeli, E.; Perrot, R.; Bomont, P.; Julien, J. P.; Kuczmarski, E.; Opal, P.; Goldman, R. D. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.J Clin Invest (2013) 123:1964-1975. 23585478; PMC3635735; 10.1172/JCI66387
Opal, P.; Goldman, R. D. Explaining intermediate filament accumulation in giant axonal neuropathy.Rare Dis (2013) 1:e25378. 25003002; 10.4161/rdis.25378
Adam, S. A.; Goldman, R. D. Insights into the differences between the A- and B-type nuclear lamins.Adv Enzyme Regul (2012) 52:108-113. 22119859; PMC3560317; 10.1016/j.advenzreg.2011.11.001
Butin-Israeli, V.; Adam, S. A.; Goldman, A. E.; Goldman, R. D. Nuclear lamin functions and disease.Trends Genet (2012) 28:464-471. 22795640; PMC3633455; 10.1016/j.tig.2012.06.001
Goldman, R. D.; Cleland, M. M.; Murthy, P.; Mahammad, S.; Kuczmarski, E. R. Inroads into the structure and function of intermediate filament networks.J Struct Biol (2012) 177:14-23. 22120848; PMC3269975; 10.1016/j.jsb.2011.11.017

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Last updated from PubMed on Monday, May 04, 2015