Cancer Center Member Publications and Abstracts Site

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C Shad Thaxton, MD, PhDEdit profile     Publications     Word cloud      
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Academic TitleAssistant Professor
DepartmentUrology; Feinberg School of Medicine
AffiliationsCancer and Physical Sciences (Member)
Translational Research in Solid Tumors (Member)
AddressLURIE 303 E Superior RM 10-113 CH
DescriptionNanotechnology is the study of the fabrication, directed self-assembly, and characterization of materials that have size dimensions between 1 and 100 nanometers. In the context of biological nanostructures, this is the size regime of the molecular machinery that constitutes, for example, functional viruses, bacteria, and human cells. The challenge of bio-nanotechnology and the focus of The Thaxton Laboratory is to control the synthesis of structures that naturally interface with biological systems to develop exquisitely targeted, practical, safe, and effective nanoparticle therapeutics, imaging agents, and biosensors.
InterestsNanotechnology, Materials Science, Biomedical Engineering, Atherosclerosis, Cancer Biology, siRNA Delivery, Drug Delivery, Biomimicry
PubMed IDs
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Publications (46)

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Foit, L.; Giles, F. J.; Gordon, L. I.; Thaxton, C. S. Synthetic high-density lipoprotein-like nanoparticles for cancer therapy.Expert Rev Anticancer Ther (2015) 15:27-34. 25487833; PMC4638421; 10.1586/14737140.2015.990889
Luthi, A. J.; Lyssenko, N. N.; Quach, D.; McMahon, K. M.; Millar, J. S.; Vickers, K. C.; Rader, D. J.; Phillips, M. C.; Mirkin, C. A.; Thaxton, C. S. Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high-density lipoprotein.J Lipid Res (2015) 56:972-985. 25652088; PMC4409287; 10.1194/jlr.M054635
McMahon, K. M.; Foit, L.; Angeloni, N. L.; Giles, F. J.; Gordon, L. I.; Thaxton, C. S. Synthetic high-density lipoprotein-like nanoparticles as cancer therapy.Cancer Treat Res (2015) 166:129-150. 25895867; PMC4418545; 10.1007/978-3-319-16555-4_6
Plebanek, M. P.; Mutharasan, R. K.; Volpert, O.; Matov, A.; Gatlin, J. C.; Thaxton, C. S. Nanoparticle Targeting and Cholesterol Flux Through Scavenger Receptor Type B-1 Inhibits Cellular Exosome Uptake.Sci Rep (2015) 5:15724. 26511855; PMC4625174; 10.1038/srep15724
Sun, W.; Kewalramani, S.; Hujsak, K.; Zhang, H.; Bedzyk, M. J.; Dravid, V. P.; Thaxton, C. S. Mesophase in a Thiolate-Containing Diacyl Phospholipid Self-Assembled Monolayer.Langmuir (2015) 31:3232-3241. 25695627; 10.1021/la504822q
Halo, T. L.; McMahon, K. M.; Angeloni, N. L.; Xu, Y.; Wang, W.; Chinen, A. B.; Malin, D.; Strekalova, E.; Cryns, V. L.; Cheng, C.; Mirkin, C. A.; Thaxton, C. S. NanoFlares for the detection, isolation, and culture of live tumor cells from human blood.Proc Natl Acad Sci U S A (2014) 111:17104-17109. 25404304; PMC4260589; 10.1073/pnas.1418637111
Tripathy, S.; Vinokour, E.; McMahon, K. M.; Volpert, O. V.; Thaxton, C. S. High Density Lipoprotein Nanoparticles Deliver RNAi to Endothelial Cells to Inhibit Angiogenesis.Part Part Syst Charact (2014) 31:1141-1150. 25400330; PMC4228967
Damiano, M. G.; Mutharasan, R. K.; Tripathy, S.; McMahon, K. M.; Thaxton, C. S. Templated high density lipoprotein nanoparticles as potential therapies and for molecular delivery.Adv Drug Deliv Rev (2013) 65:649-662. 22921597; 10.1016/j.addr.2012.07.013
Rink, J. S.; McMahon, K. M.; Zhang, X.; Chen, X.; Mirkin, C. A.; Thaxton, C. S.; Kaufman, D. B. Knockdown of Intraislet IKKbeta by Spherical Nucleic Acid Conjugates Prevents Cytokine-Induced Injury and Enhances Graft Survival.Transplantation (2013) 96:877-884. 24247900; PMC3839058; 10.1097/TP.0b013e3182a4190e
Rink, J. S.; Plebanek, M. P.; Tripathy, S.; Thaxton, C. S. Update on current and potential nanoparticle cancer therapies.Curr Opin Oncol (2013) 25:646-651. 24097107; PMC4089948; 10.1097/CCO.0000000000000012
Rose, S.; Eren, M.; Murphy, S.; Zhang, H.; Thaxton, C. S.; Chowaniec, J.; Waters, E. A.; Meade, T. J.; Vaughan, D. E.; Perlman, H. A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis.Ann Rheum Dis (2013) 72:89-95. 22736097; PMC3551222; 10.1136/annrheumdis-2012-201431
Yang, S.; Damiano, M. G.; Zhang, H.; Tripathy, S.; Luthi, A. J.; Rink, J. S.; Ugolkov, A. V.; T K Singh, A.; Dave, S. S.; Gordon, L. I.; Thaxton, C. S. Biomimetic, synthetic HDL nanostructures for lymphoma.Proc Natl Acad Sci U S A (2013) 110:2511-2516. 23345442; PMC3574906; 10.1073/pnas.1213657110
Alhasan, A. H.; Kim, D. Y.; Daniel, W. L.; Watson, E.; Meeks, J. J.; Thaxton, C. S.; Mirkin, C. A. Scanometric MicroRNA Array Profiling of Prostate Cancer Markers Using Spherical Nucleic Acid-Gold Nanoparticle Conjugates.Anal Chem (2012) 84:4153-4160. 22489825; PMC3357313; 10.1021/ac3004055
Luthi, A. J.; Zhang, H.; Kim, D.; Giljohann, D. A.; Mirkin, C. A.; Thaxton, C. S. Tailoring of Biomimetic High-Density Lipoprotein (HDL) Nanostructures Changes Cholesterol Binding and Efflux.ACS Nano (2012) 6:276-285. 22117189; 10.1021/nn2035457
Eifler, A. C.; Thaxton, C. S. Nanoparticle Therapeutics: FDA Approval, Clinical Trials, Regulatory Pathways, and Case Study.Methods Mol Biol (2011) 726:325-338. 21424459; 10.1007/978-1-61779-052-2_21
Kieger, A.; Wiester, M. J.; Procissi, D.; Parrish, T. B.; Mirkin, C. A.; Thaxton, C. S. Hybridization-Induced "Off-On" (19) F-NMR Signal Probe Release from DNA-Functionalized Gold Nanoparticles.Small (2011) 7:1977-1981. 21661107; 10.1002/smll.201100566
McMahon, K. M.; Mutharasan, R. K.; Tripathy, S.; Veliceasa, D.; Bobeica, M.; Shumaker, D. K.; Luthi, A. J.; Helfand, B. T.; Ardehali, H.; Mirkin, C. A.; Volpert, O.; Thaxton, C. S. Biomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery.Nano Lett (2011) 11:1208-1214. 21319839; 10.1021/nl1041947
Luthi, A. J.; Patel, P. C.; Ko, C. H.; Mutharasan, R. K.; Mirkin, C. A.; Thaxton, C. S. Nanotechnology for synthetic high-density lipoproteins.Trends Mol Med (2010) 16:553-560. 21087901; 10.1016/j.molmed.2010.10.006
Mouli, S. K.; Zhao, L. C.; Omary, R. A.; Thaxton, C. S. Lymphotropic nanoparticle enhanced MRI for the staging of genitourinary tumors.Nat Rev Urol (2010) 7:84-93. 20084078; 10.1038/nrurol.2009.254
Rink, J. S.; McMahon, K. M.; Chen, X.; Mirkin, C. A.; Thaxton, C. S.; Kaufman, D. B. Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles.Surgery (2010) 148:335-345. 20633730; PMC3150467; 10.1016/j.surg.2010.05.013

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Last updated from PubMed on Wednesday, November 25, 2015