Cancer Center Member Publications and Abstracts Site

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Anjen Chenn, MD, PhDEdit profile     Publications     Word cloud      
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Academic TitleAssociate Professor
DepartmentDepartment of Pathology, Feinberg School of Medicine
Descriptiondevelopmental neurobiology
molecular diagnostics
clinical pathology
Research Interests

Our major research interest is understanding the factors that control cell proliferation and differentiation in the developing mammalian central nervous system. Although the mechanisms that regulate cell proliferation during neural development are poorly understood, studies in other tissues suggest that loss of normal cell polarity and tissue architecture play crucial regulatory roles in cell proliferation and cancer. Our most recent work suggests that beta catenin, an integral component of the adherens junction, can regulate cell cycle re-entry and differentiation in the developing mammalian brain. Transgenic mice expressing a truncated, stabilized form of beta catenin develop massively enlarged brains with increased cerebral cortical surface area and folds resembling sulci and gyri of higher mammals. Understanding the biology of epithelial organization can lend insight onto the regulation of proliferation during neural development and ultimately reveal mechanisms underlying developmental brain disorders and tumors in the central nervous system.
InterestsCancer Biology, Developmental Neurobiology, Nervous System Diseases, Neuroscience

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Last updated from PubMed on Monday, May 04, 2015