|Academic Title||Associate Professor|
|Department||Department of Pathology, Feinberg School of Medicine|
Our major research interest is understanding the factors that control cell proliferation and differentiation in the developing mammalian central nervous system. Although the mechanisms that regulate cell proliferation during neural development are poorly understood, studies in other tissues suggest that loss of normal cell polarity and tissue architecture play crucial regulatory roles in cell proliferation and cancer. Our most recent work suggests that beta catenin, an integral component of the adherens junction, can regulate cell cycle re-entry and differentiation in the developing mammalian brain. Transgenic mice expressing a truncated, stabilized form of beta catenin develop massively enlarged brains with increased cerebral cortical surface area and folds resembling sulci and gyri of higher mammals. Understanding the biology of epithelial organization can lend insight onto the regulation of proliferation during neural development and ultimately reveal mechanisms underlying developmental brain disorders and tumors in the central nervous system.
|Interests||Cancer Biology, Developmental Neurobiology, Nervous System Diseases, Neuroscience||
Last updated from PubMed on Monday, May 04, 2015